4IXC

Crystal structure of Human Glucokinase in complex with a small molecule activator.

4IXC の概要

• エントリーDOI: 10.2210/pdb4ixc/pdb
• 分子名称: Glucokinase isoform 3, SODIUM ION, alpha-D-glucopyranose, ... (5 entities in total)
• 機能のキーワード: allosteric regulation, binding sites, catalytic domain, diabetes mellitus, type 2, enzyme activators, glucokinase, hexokinase, humans, models, molecular, mutation, protein conformation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 51478.73

構造登録者

Ogg, D.J.,Hargreaves, D.,Gerhardt, S. (登録日: 2013-01-25, 公開日: 2013-04-24, 最終更新日: 2020-07-29)

• 主引用文献: Waring, M.J.,Bennett, S.N.L.,Boyd, S.,Campbell, L.,Davies, R.D.M.,Gerhardt, S.,Hargreaves, D.,G Martin, N.,Robb, G.R.,Wilkinson, G.; Matched triplicate design sets in the optimisation of glucokinase activators maximising medicinal chemistry information content; To be Published,

実験手法

X-RAY DIFFRACTION (2 Å)