4IWZ

structure of hCAII in complex with an acetazolamide derivative

4IWZ の概要

• エントリーDOI: 10.2210/pdb4iwz/pdb
• 分子名称: Carbonic anhydrase 2, N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)-2-(thiophen-2-yl)acetamide, ZINC ION, ... (6 entities in total)
• 機能のキーワード: alpha beta fold, reversible hydration of carbon di oxide to bicarbonate and proton, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29656.83

構造登録者

Biswas, S.,McKenna, R. (登録日: 2013-01-24, 公開日: 2013-12-11, 最終更新日: 2024-02-28)

• 主引用文献: Biswas, S.,McKenna, R.,Supuran, C.T.; Effect of incorporating a thiophene tail in the scaffold of acetazolamide on the inhibition of human carbonic anhydrase isoforms I, II, IX and XII.; Bioorg.Med.Chem.Lett., 23:5646-5649, 2013; PubMed: 23993330; DOI: 10.1016/j.bmcl.2013.08.019

実験手法

X-RAY DIFFRACTION (1.598 Å)