4ITI
Crystal structure of RIP1 kinase in complex with necrostatin-3 analog
Summary for 4ITI
Entry DOI | 10.2210/pdb4iti/pdb |
Related | 4ITH 4ITJ |
Descriptor | Receptor-interacting serine/threonine-protein kinase 1, 1-{(3S,3aS)-3-[3-fluoro-4-(trifluoromethoxy)phenyl]-8-methoxy-3,3a,4,5-tetrahydro-2H-benzo[g]indazol-2-yl}-2-hydroxyethanone (2 entities in total) |
Functional Keywords | alpha/beta, rip1 kinase, necroptosis, necrostatins, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q13546 |
Total number of polymer chains | 2 |
Total formula weight | 67814.20 |
Authors | |
Primary citation | Xie, T.,Peng, W.,Liu, Y.,Yan, C.,Maki, J.,Degterev, A.,Yuan, J.,Shi, Y. Structural Basis of RIP1 Inhibition by Necrostatins. Structure, 21:493-499, 2013 Cited by PubMed: 23473668DOI: 10.1016/j.str.2013.01.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.86 Å) |
Structure validation
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