4ITH
Crystal structure of RIP1 kinase in complex with necrostatin-1 analog
Summary for 4ITH
Entry DOI | 10.2210/pdb4ith/pdb |
Related | 4ITI 4ITJ |
Descriptor | Receptor-interacting serine/threonine-protein kinase 1, IODIDE ION, SODIUM ION, ... (5 entities in total) |
Functional Keywords | alpha/beta, rip1 kinase, necroptosis, necrostatins, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q13546 |
Total number of polymer chains | 2 |
Total formula weight | 68807.89 |
Authors | |
Primary citation | Xie, T.,Peng, W.,Liu, Y.,Yan, C.,Maki, J.,Degterev, A.,Yuan, J.,Shi, Y. Structural Basis of RIP1 Inhibition by Necrostatins. Structure, 21:493-499, 2013 Cited by PubMed: 23473668DOI: 10.1016/j.str.2013.01.016 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.25 Å) |
Structure validation
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