4ITD

Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing transition mutation

4ITD の概要

• エントリーDOI: 10.2210/pdb4itd/pdb
• 関連するPDBエントリー: 4IJ0
• 分子名称: DNA (5'-D(*CP*GP*CP*GP*(C6G)P*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION, 2'-(4-HYDROXYPHENYL)-5-(4-METHYL-1-PIPERAZINYL)-2,5'-BI-BENZIMIDAZOLE, ... (4 entities in total)
• 機能のキーワード: damaged dna, o6-carboxymethylguanine, mutagenesis, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7923.66

構造登録者

Zhang, F.,Suzuki, K.,Tsunoda, M.,Wilkinson, O.,Millington, C.L.,Williams, D.M.,Morishita, E.C.,Takenaka, A. (登録日: 2013-01-18, 公開日: 2013-05-08, 最終更新日: 2024-03-20)

• 主引用文献: Zhang, F.,Tsunoda, M.,Suzuki, K.,Kikuchi, Y.,Wilkinson, O.,Millington, C.L.,Margison, G.P.,Williams, D.M.,Czarina Morishita, E.,Takenaka, A.; Structures of DNA duplexes containing O6-carboxymethylguanine, a lesion associated with gastrointestinal cancer, reveal a mechanism for inducing pyrimidine transition mutations; Nucleic Acids Res., 41:5524-5532, 2013; PubMed: 23580550; DOI: 10.1093/nar/gkt198

実験手法

X-RAY DIFFRACTION (1.94 Å)