4ISL
Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1
Summary for 4ISL
Entry DOI | 10.2210/pdb4isl/pdb |
Related | 4IS5 4ISN 4ISO |
Descriptor | Kunitz-type protease inhibitor 1, Suppressor of tumorigenicity 14 protein, TETRAETHYLENE GLYCOL, ... (7 entities in total) |
Functional Keywords | beta barrel, serine protease inhibitor, epithelium, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: O43278 Membrane ; Single-pass type II membrane protein : Q9Y5Y6 |
Total number of polymer chains | 2 |
Total formula weight | 34331.61 |
Authors | Huang, M.D.,Zhao, B.Y.,Yuan, C.,Li, R. (deposition date: 2013-01-16, release date: 2013-03-06, Last modification date: 2023-09-20) |
Primary citation | Zhao, B.,Yuan, C.,Li, R.,Qu, D.,Huang, M.,Ngo, J.C. Crystal structures of matriptase in complex with its inhibitor hepatocyte growth factor activator inhibitor-1. J.Biol.Chem., 288:11155-11164, 2013 Cited by PubMed: 23443661DOI: 10.1074/jbc.M113.454611 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.29 Å) |
Structure validation
Download full validation report