4ISH

Structure of FACTOR VIIA in complex with the inhibitor BMS-593214 also known as 2'-[(6R,6AR,11BR)-2-CARBAMIMIDOYL-6,6A,7,11B-TETRAHYDRO-5H-INDENO[2,1-C]QUINOLIN-6-YL]-5'-HYDROXY-4'-METHOXYBIPHENYL-4-CARBOXYLIC ACID

4ISH の概要

• エントリーDOI: 10.2210/pdb4ish/pdb
• 関連するPDBエントリー: 4ISI
• 分子名称: Factor VII heavy chain, Factor VII light chain, 2'-[(6R,6aR,11bR)-2-carbamimidoyl-6,6a,7,11b-tetrahydro-5H-indeno[2,1-c]quinolin-6-yl]-5'-hydroxy-4'-methoxybiphenyl-4-carboxylic acid, ... (5 entities in total)
• 機能のキーワード: glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium-binding, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Secreted: P08709 P08709
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 34679.72

構造登録者

Wei, A. (登録日: 2013-01-16, 公開日: 2013-03-20)

• 主引用文献: Priestley, E.S.,De Lucca, I.,Zhou, J.,Zhou, J.,Saiah, E.,Stanton, R.,Robinson, L.,Luettgen, J.M.,Wei, A.,Wen, X.,Knabb, R.M.,Wong, P.C.,Wexler, R.R.; Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor.; Bioorg.Med.Chem.Lett., 23:2432-2435, 2013; PubMed: 23478148; DOI: 10.1016/j.bmcl.2013.02.013

実験手法

X-RAY DIFFRACTION (1.82 Å)