4IQK
Crystal structure of cpd 16 bound to Keap1 Kelch domain
Summary for 4IQK
Entry DOI | 10.2210/pdb4iqk/pdb |
Related | 4IN4 |
Descriptor | Kelch-like ECH-associated protein 1, N,N'-naphthalene-1,4-diylbis(4-methoxybenzenesulfonamide) (3 entities in total) |
Functional Keywords | transcription |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q14145 |
Total number of polymer chains | 1 |
Total formula weight | 33060.08 |
Authors | Silvian, L.,Marcotte, D. (deposition date: 2013-01-11, release date: 2013-05-15, Last modification date: 2013-07-03) |
Primary citation | Marcotte, D.,Zeng, W.,Hus, J.C.,McKenzie, A.,Hession, C.,Jin, P.,Bergeron, C.,Lugovskoy, A.,Enyedy, I.,Cuervo, H.,Wang, D.,Atmanene, C.,Roecklin, D.,Vecchi, M.,Vivat, V.,Kraemer, J.,Winkler, D.,Hong, V.,Chao, J.,Lukashev, M.,Silvian, L. Small molecules inhibit the interaction of Nrf2 and the Keap1 Kelch domain through a non-covalent mechanism. Bioorg.Med.Chem., 21:4011-4019, 2013 Cited by PubMed: 23647822DOI: 10.1016/j.bmc.2013.04.019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.97 Å) |
Structure validation
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