4IOC

Crystal structure of compound 4f bound to large ribosomal subunit (50S) from Deinococcus radiodurans

4IOC の概要

• エントリーDOI: 10.2210/pdb4ioc/pdb
• 関連するPDBエントリー: 4IO9 4IOA
• 分子名称: 23S ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (32 entities in total)
• 機能のキーワード: ribosome-ribosome inhibitor complex, ribosome/ribosome inhibitor
• 由来する生物種: Deinococcus radiodurans; 詳細
• タンパク質・核酸の鎖数: 30
• 化学式量合計: 1365975.10

構造登録者

Han, S.,Marr, E.S. (登録日: 2013-01-07, 公開日: 2013-03-06, 最終更新日: 2024-10-30)

主引用文献

Magee, T.V.,Han, S.,McCurdy, S.P.,Nguyen, T.T.,Granskog, K.,Marr, E.S.,Maguire, B.A.,Huband, M.D.,Chen, J.M.,Subashi, T.A.,Shanmugasundaram, V.
Novel 3-O-carbamoyl erythromycin A derivatives (carbamolides) with activity against resistant staphylococcal and streptococcal isolates.
Bioorg.Med.Chem.Lett., 23:1727-1731, 2013

PubMed Abstract: A novel series of 3-O-carbamoyl erythromycin A derived analogs, labeled carbamolides, with activity versus resistant bacterial isolates of staphylococci (including macrolide and oxazolidinone resistant strains) and streptococci are reported. An (R)-2-aryl substituent on a pyrrolidine carbamate appeared to be critical for achieving potency against resistant strains. Crystal structures showed a distinct aromatic interaction between the (R)-2-aryl (3-pyridyl for 4d) substituent on the pyrrolidine and G2484 (G2505, Escherichia coli) of the Deinococcus radiodurans 50S ribosome (3.2Å resolution).

PubMed: 23414806
DOI: 10.1016/j.bmcl.2013.01.067

実験手法

X-RAY DIFFRACTION (3.6 Å)