4IO8

Crystal structure of human HSP70 complexed with 4-{(2R,3S,4R)-5-[(R)-6-Amino-8-(3,4-dichloro-benzylamino)-purin-9-yl]-3,4-dihydroxy-tetrahydro-furan-2-ylmethoxymethyl}-benzonitrile

4IO8 の概要

• エントリーDOI: 10.2210/pdb4io8/pdb
• 分子名称: Heat shock 70kDa protein 1A variant, 4-[[(2R,3S,4R,5R)-5-[6-amino-8-[(3,4-dichlorophenyl)methylamino]purin-9-yl]-3,4-dihydroxy-oxolan-2-yl]methoxymethyl]benzonitrile (3 entities in total)
• 機能のキーワード: hsp70, atpase, molecular chaperone, chaperone
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42627.04

構造登録者

Musil, D.,Scholz, S. (登録日: 2013-01-07, 公開日: 2013-12-18, 最終更新日: 2023-09-20)

• 主引用文献: Schlecht, R.,Scholz, S.R.,Dahmen, H.,Wegener, A.,Sirrenberg, C.,Musil, D.,Bomke, J.,Eggenweiler, H.M.,Mayer, M.P.,Bukau, B.; Functional analysis of hsp70 inhibitors.; Plos One, 8:e78443-e78443, 2013; PubMed: 24265689; DOI: 10.1371/journal.pone.0078443

実験手法

X-RAY DIFFRACTION (2.58 Å)