4INU
Yeast 20S proteasome in complex with the vinyl sulfone LU112
Summary for 4INU
Entry DOI | 10.2210/pdb4inu/pdb |
Related | 1RYP 4INR 4INT |
Related PRD ID | PRD_000993 |
Descriptor | Proteasome component Y7, Proteasome component C11, Proteasome component PRE2, ... (16 entities in total) |
Functional Keywords | ups, drug discovery, irreversible inhibition, ntn hydrolase, non-lysosomal protein breakdown, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Saccharomyces cerevisiae (Baker's yeast) More |
Cellular location | Cytoplasm: P23639 P22141 P30656 P23724 P30657 P38624 P23638 P40303 P32379 P40302 P21242 P21243 P25043 P25451 |
Total number of polymer chains | 28 |
Total formula weight | 731415.61 |
Authors | Geurink, P.P.,van der Linden, W.A.,Mirabella, A.C.,Gallastegui, N.,de Bruin, G.,Blom, A.E.M.,Voges, M.J.,Mock, E.D.,Florea, B.I.,van der Marel, G.A.,Driessen, C.,van der Stelt, M.,Groll, M.,Overkleeft, H.S.,Kisselev, A.F. (deposition date: 2013-01-06, release date: 2013-01-30, Last modification date: 2023-09-20) |
Primary citation | Geurink, P.P.,van der Linden, W.A.,Mirabella, A.C.,Gallastegui, N.,de Bruin, G.,Blom, A.E.,Voges, M.J.,Mock, E.D.,Florea, B.I.,van der Marel, G.A.,Driessen, C.,van der Stelt, M.,Groll, M.,Overkleeft, H.S.,Kisselev, A.F. Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites. J.Med.Chem., 56:1262-1275, 2013 Cited by PubMed: 23320547DOI: 10.1021/jm3016987 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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