4INB

Crystal Structure of the N-Terminal Domain of HIV-1 Capsid in Complex With benzodiazepine Inhibitor

4INB の概要

• エントリーDOI: 10.2210/pdb4inb/pdb
• 関連するPDBエントリー: 4E91 4E92
• 分子名称: Gag protein, (3Z)-3-{[(2-methoxyethyl)amino]methylidene}-1-methyl-5-phenyl-7-(trifluoromethyl)-1H-1,5-benzodiazepine-2,4(3H,5H)-dione, SODIUM ION, ... (4 entities in total)
• 機能のキーワード: structural protein, capsid, viral protein, viral protein-viral protein inhibitor complex, viral protein/viral protein inhibitor
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Capsid protein p24: Virion (By similarity). Matrix protein p17: Virion (By similarity). Nucleocapsid protein p7: Virion (By similarity): Q79791
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16646.96

構造登録者

Coulombe, R. (登録日: 2013-01-04, 公開日: 2013-02-27, 最終更新日: 2024-02-28)

• 主引用文献: Goudreau, N.,Coulombe, R.,Faucher, A.M.,Grand-Maitre, C.,Lacoste, J.E.,Lemke, C.T.,Malenfant, E.,Bousquet, Y.,Fader, L.,Simoneau, B.,Mercier, J.F.,Titolo, S.,Mason, S.W.; Monitoring Binding of HIV-1 Capsid Assembly Inhibitors Using (19) F Ligand-and (15) N Protein-Based NMR and X-ray Crystallography: Early Hit Validation of a Benzodiazepine Series.; Chemmedchem, 8:405-414, 2013; PubMed: 23401268; DOI: 10.1002/cmdc.201200580

実験手法

X-RAY DIFFRACTION (1.8 Å)