4IM6

LRR domain from human NLRP1

4IM6 の概要

• エントリーDOI: 10.2210/pdb4im6/pdb
• 分子名称: NACHT, LRR and PYD domains-containing protein 1, GLYCEROL (3 entities in total)
• 機能のキーワード: lrr domain, ligand recognition, muramyl dipeptide, structural protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 22901.53

構造登録者

Hahne, G.,Reubold, T.F.,Eschenburg, S. (登録日: 2013-01-02, 公開日: 2014-01-08, 最終更新日: 2024-10-16)

主引用文献

Reubold, T.F.,Hahne, G.,Wohlgemuth, S.,Eschenburg, S.
Crystal structure of the leucine-rich repeat domain of the NOD-like receptor NLRP1: implications for binding of muramyl dipeptide.
Febs Lett., 588:3327-3332, 2014

PubMed Abstract: The NOD-like receptor NLRP1 (NLR family, pyrin domain containing 1) senses the presence of the bacterial cell wall component l-muramyl dipeptide (MDP) inside the cell. We determined the crystal structure of the LRR domain of human NLRP1 in the absence of MDP to a resolution of 1.65Å. The fold of the structure can be assigned to the ribonuclease inhibitor-like class of LRR proteins. We compared our structure with X-ray models of the LRR domains of NLRX1 and NLRC4 and a homology model of the LRR domain of NOD2. We conclude that the MDP binding site of NLRP1 is not located in the LRR domain.

PubMed: 25064844
DOI: 10.1016/j.febslet.2014.07.017

実験手法

X-RAY DIFFRACTION (1.65 Å)