4IKF

PFV intasome with inhibitor MB-76

4IKF の概要

• エントリーDOI: 10.2210/pdb4ikf/pdb
• 分子名称: Integrase, N-(4-fluorobenzyl)-2,3-dihydroxy-1-oxo-1,2-dihydroisoquinoline-4-carboxamide, 5'-D(*AP*TP*TP*GP*TP*CP*AP*TP*GP*GP*AP*AP*TP*TP*TP*CP*GP*CP*A)-3', ... (10 entities in total)
• 機能のキーワード: integrase zinc binding, core and dna-binding domains, dna integration, inhibitor, nucleus, viral protein-dna-inhibitor complex, endonuclease, nucleotidyltransferase, recombination, hhcc motif, dde motif, viral protein/dna/inhibitor
• 由来する生物種: Human spumaretrovirus (SFVcpz(hu))
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 101082.61

構造登録者

Taltynov, O.,Demeulemeester, J.,Desimmie, B.A.,Suchaud, V.,Billamboz, M.,Lion, C.,Bailly, F.,Debyser, Z.,Cotelle, P.,Christ, F.,Strelkov, S.V. (登録日: 2012-12-26, 公開日: 2013-04-03, 最終更新日: 2024-02-28)

• 主引用文献: Desimmie, B.A.,Demeulemeester, J.,Suchaud, V.,Taltynov, O.,Billamboz, M.,Lion, C.,Bailly, F.,Strelkov, S.V.,Debyser, Z.,Cotelle, P.,Christ, F.; 2-Hydroxyisoquinoline-1,3(2H,4H)-diones (HIDs), novel inhibitors of HIV integrase with a high barrier to resistance.; Acs Chem.Biol., 8:1187-1194, 2013; PubMed: 23517458; DOI: 10.1021/cb4000426

実験手法

X-RAY DIFFRACTION (3.4 Å)