4II2

Crystal structure of Ubiquitin activating enzyme 1 (Uba1) in complex with the Ub E2 Ubc4, ubiquitin, and ATP/Mg

4II2 の概要

• エントリーDOI: 10.2210/pdb4ii2/pdb
• 関連するPDBエントリー: 4II3
• 分子名称: Ubiquitin-activating enzyme E1 1, Ubiquitin-60S ribosomal protein L40, Ubiquitin-conjugating enzyme E2 4, ... (9 entities in total)
• 機能のキーワード: ubiquitin, e1, e2, uba1, ubc4, conformational change, thioester, adenylation, thioester transfer (transthioesterification), atp-binding, rossmann-like fold, ubiquitin-like fold, ligase activity, atp/mg binding, ubiquitin e2 binding, ubiquitination, nucleus, ligase
• 由来する生物種: Schizosaccharomyces pombe (Fission yeast); 詳細
• 細胞内の位置: Cytoplasm: O94609; Ubiquitin: Cytoplasm . 60S ribosomal protein L40: Cytoplasm : P0CH07
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 141137.09

構造登録者

Olsen, S.K.,Lima, C.D. (登録日: 2012-12-19, 公開日: 2013-02-13, 最終更新日: 2023-09-20)

• 主引用文献: Olsen, S.K.,Lima, C.D.; Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer.; Mol.Cell, 49:884-896, 2013; PubMed: 23416107; DOI: 10.1016/j.molcel.2013.01.013

実験手法

X-RAY DIFFRACTION (2.2 Å)