4IGT

Crystal structure of the GluA2 ligand-binding domain (S1S2J) in complex with the agonist ZA302 at 1.24A resolution

4IGT の概要

• エントリーDOI: 10.2210/pdb4igt/pdb
• 分子名称: Glutamate receptor 2, (4R)-4-{3-[hydroxy(methyl)amino]-3-oxopropyl}-L-glutamic acid, SULFATE ION, ... (6 entities in total)
• 機能のキーワード: ampa receptor ligand-binding domain, glur2-s1s2j, agonist, membrane protein
• 由来する生物種: Rattus norvegicus (rat); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P19491
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30133.42

構造登録者

Larsen, A.P.,Venskutonyte, R.,Gajhede, M.,Kastrup, J.S.,Frydenvang, K. (登録日: 2012-12-18, 公開日: 2013-03-06, 最終更新日: 2023-11-08)

• 主引用文献: Assaf, Z.,Larsen, A.P.,Venskutonyte, R.,Han, L.,Abrahamsen, B.,Nielsen, B.,Gajhede, M.,Kastrup, J.S.,Jensen, A.A.,Pickering, D.S.,Frydenvang, K.,Gefflaut, T.,Bunch, L.; Chemoenzymatic synthesis of new 2,4-syn-functionalized (S)-glutamate analogues and structure-activity relationship studies at ionotropic glutamate receptors and excitatory amino acid transporters.; J.Med.Chem., 56:1614-1628, 2013; PubMed: 23414088; DOI: 10.1021/jm301433m

実験手法

X-RAY DIFFRACTION (1.24 Å)