4IGD
Crystal structure of the zymogen catalytic region of Human MASP-1
Summary for 4IGD
Entry DOI | 10.2210/pdb4igd/pdb |
Descriptor | Mannan-binding lectin serine protease 1, GLYCEROL (3 entities in total) |
Functional Keywords | complement, immune response, innate immunity, beta barrel, hydrolase, serine protease, glycosylation |
Biological source | Homo sapiens (human) |
Cellular location | Secreted: P48740 |
Total number of polymer chains | 1 |
Total formula weight | 45674.11 |
Authors | Harmat, V.,Megyeri, M.,Vegh, A.,Dobo, J. (deposition date: 2012-12-17, release date: 2013-02-13, Last modification date: 2023-11-08) |
Primary citation | Megyeri, M.,Harmat, V.,Major, B.,Vegh, A.,Balczer, J.,Heja, D.,Szilagyi, K.,Datz, D.,Pal, G.,Zavodszky, P.,Gal, P.,Dobo, J. Quantitative characterization of the activation steps of mannan-binding lectin (MBL)-associated serine proteases (MASPs) points to the central role of MASP-1 in the initiation of the complement lectin pathway J.Biol.Chem., 288:8922-8934, 2013 Cited by PubMed: 23386610DOI: 10.1074/jbc.M112.446500 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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