4IFV

Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-Ray Crystallographic Fragment Screening

4IFV の概要

• エントリーDOI: 10.2210/pdb4ifv/pdb
• 関連するPDBエントリー: 4ICL 4ID5 4IDK 4IFY 4IG0 4IG3 4IG7
• 分子名称: Exoribonuclease H, p66 RT, Gag-Pol polyprotein, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ... (7 entities in total)
• 機能のキーワード: rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1); 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 115748.40

構造登録者

Bauman, J.D.,Patel, D.,Fromer, M.,Arnold, E. (登録日: 2012-12-15, 公開日: 2013-02-06, 最終更新日: 2024-02-28)

• 主引用文献: Bauman, J.D.,Patel, D.,Dharia, C.,Fromer, M.W.,Ahmed, S.,Frenkel, Y.,Vijayan, R.S.,Eck, J.T.,Ho, W.C.,Das, K.,Shatkin, A.J.,Arnold, E.; Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening.; J.Med.Chem., 56:2738-2746, 2013; PubMed: 23342998; DOI: 10.1021/jm301271j

実験手法

X-RAY DIFFRACTION (2.05 Å)