4IC9

Crystal structure of the full-length matrix subunit (p15) of the Feline Immunodeficiency Virus (FIV) Gag polyprotein

Summary for 4IC9

Entry DOI	10.2210/pdb4ic9/pdb
Related	4ICA
Descriptor	Matrix protein p15, 1,2-ETHANEDIOL (3 entities in total)
Functional Keywords	fiv, p15, retroviral matrix protein, viral protein
Biological source	Feline immunodeficiency virus (FIV)
Cellular location	Matrix protein p15: Virion . Capsid protein p24: Virion . Nucleocapsid protein p13: Virion : P16087
Total number of polymer chains	1
Total formula weight	16607.00
Authors	Serriere, J.,Robert, X.,Perez, M.,Gouet, P.,Guillon, C. (deposition date: 2012-12-10, release date: 2013-07-10, Last modification date: 2023-09-20)
Primary citation	Serriere, J.,Robert, X.,Perez, M.,Gouet, P.,Guillon, C. Biophysical characterization and crystal structure of the Feline Immunodeficiency Virus p15 matrix protein. Retrovirology, 10:64-64, 2013 Cited by PubMed Abstract: Feline Immunodeficiency Virus (FIV) is a viral pathogen that infects domestic cats and wild felids. During the viral replication cycle, the FIV p15 matrix protein oligomerizes to form a closed matrix that underlies the lipidic envelope of the virion. Because of its crucial role in the early and late stages of viral morphogenesis, especially in viral assembly, FIV p15 is an interesting target in the development of potential new therapeutic strategies. PubMed: 23800358 DOI: 10.1186/1742-4690-10-64 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation