4IBV

Human p53 core domain with hot spot mutation R273C and second-site suppressor mutation S240R in sequence-specific complex with DNA

4IBV の概要

• エントリーDOI: 10.2210/pdb4ibv/pdb
• 関連するPDBエントリー: 4IBQ 4IBS 4IBT 4IBU 4IBW 4IBY 4IBZ 4IJT
• 分子名称: Cellular tumor antigen p53, DNA (5'-D(*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*G)-3'), 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: metal-binding, loop-sheet-helix motif, transcription, activator, anti-oncogene, apoptosis, cell cycle, disease mutation, rescue mutation, tumor suppressor, dna binding protein-dna complex, dna binding protein/dna
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 26685.91

構造登録者

Eldar, A.,Rozenberg, H.,Diskin-Posner, Y.,Shakked, Z. (登録日: 2012-12-09, 公開日: 2013-08-14, 最終更新日: 2023-09-20)

• 主引用文献: Eldar, A.,Rozenberg, H.,Diskin-Posner, Y.,Rohs, R.,Shakked, Z.; Structural studies of p53 inactivation by DNA-contact mutations and its rescue by suppressor mutations via alternative protein-DNA interactions.; Nucleic Acids Res., 41:8748-8759, 2013; PubMed: 23863845; DOI: 10.1093/nar/gkt630

実験手法

X-RAY DIFFRACTION (2.1 Å)