4IBM

Crystal structure of insulin receptor kinase domain in complex with an inhibitor Irfin-1

Summary for 4IBM

Entry DOI	10.2210/pdb4ibm/pdb
Descriptor	Insulin receptor, 5-(2-phenylpyrazolo[1,5-a]pyridin-3-yl)-3H-pyrazolo[3,4-c]pyridazin-3-one (3 entities in total)
Functional Keywords	irk, kinase, atp binding, phosphorylation, membrane, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cell membrane; Single-pass type I membrane protein: P06213
Total number of polymer chains	2
Total formula weight	70272.21
Authors	Wu, J.,Anastassiadis, T.,Duong-Ly, K.C.,Peterson, J.R. (deposition date: 2012-12-08, release date: 2013-08-21, Last modification date: 2024-02-28)
Primary citation	Anastassiadis, T.,Duong-Ly, K.C.,Deacon, S.W.,Lafontant, A.,Ma, H.,Devarajan, K.,Dunbrack, R.L.,Wu, J.,Peterson, J.R. A highly selective dual insulin receptor (IR)/insulin-like growth factor 1 receptor (IGF-1R) inhibitor derived from an extracellular signal-regulated kinase (ERK) inhibitor. J.Biol.Chem., 288:28068-28077, 2013 Cited by PubMed: 23935097 DOI: 10.1074/jbc.M113.505032 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation