4IBE

Ebola virus VP35 bound to small molecule

4IBE の概要

• エントリーDOI: 10.2210/pdb4ibe/pdb
• 関連するPDBエントリー: 4IBB 4IBC 4IBD 4IBF 4IBG 4IBH 4IBI 4IBJ 4IBK
• 分子名称: Polymerase cofactor VP35, 5-[(2R)-3-benzoyl-2-(4-bromothiophen-2-yl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-2-chlorobenzoic acid, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: structural genomics, niaid, national institute of allergy and infectious diseases, center for structural genomics of infectious diseases, csgid, interferon inhibitor domain, transcription-transcription inhibitor complex, transcription/transcription inhibitor
• 由来する生物種: Ebola virus (ZEBOV)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29550.67

構造登録者

Brown, C.S.,Leung, D.W.,Xu, W.,Borek, D.M.,Otwinowski, Z.,Ramanan, P.,Stubbs, A.J.,Peterson, D.S.,Binning, J.M.,Amarasinghe, G.K.,Center for Structural Genomics of Infectious Diseases (CSGID) (登録日: 2012-12-08, 公開日: 2014-03-19, 最終更新日: 2024-02-28)

• 主引用文献: Brown, C.S.,Lee, M.S.,Leung, D.W.,Wang, T.,Xu, W.,Luthra, P.,Anantpadma, M.,Shabman, R.S.,Melito, L.M.,Macmillan, K.S.,Borek, D.M.,Otwinowski, Z.,Ramanan, P.,Stubbs, A.J.,Peterson, D.S.,Binning, J.M.,Tonelli, M.,Olson, M.A.,Davey, R.A.,Ready, J.M.,Basler, C.F.,Amarasinghe, G.K.; In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity.; J.Mol.Biol., 426:2045-2058, 2014; PubMed: 24495995; DOI: 10.1016/j.jmb.2014.01.010

実験手法

X-RAY DIFFRACTION (1.95 Å)