4IAX

Engineered human lipocalin 2 (CL31) in complex with Y-DTPA

Summary for 4IAX

Entry DOI	10.2210/pdb4iax/pdb
Related	3DSZ 3DTQ 4IAW
Descriptor	Neutrophil gelatinase-associated lipocalin, N-{(1S,2S)-2-[bis(carboxymethyl)amino]cyclohexyl}-N-{(2R)-2-[bis(carboxymethyl)amino]-3-[4-({[2-hydroxy-1,1-bis(hydroxymethyl)ethyl]carbamothioyl}amino)phenyl]propyl}glycine, YTTRIUM (III) ION, ... (4 entities in total)
Functional Keywords	beta-barrel, engineered lipocalin, binding protein, y-chx-a''-dtpa, strep-tag, transport protein
Biological source	Homo sapiens (human)
Cellular location	Secreted: P80188
Total number of polymer chains	1
Total formula weight	22370.17
Authors	Eichinger, A.,Skerra, A. (deposition date: 2012-12-07, release date: 2013-06-19, Last modification date: 2023-11-08)
Primary citation	Eggenstein, E.,Eichinger, A.,Kim, H.J.,Skerra, A. Structure-guided engineering of Anticalins with improved binding behavior and biochemical characteristics for application in radio-immuno imaging and/or therapy J.Struct.Biol., 185:203-214, 2014 Cited by PubMed: 23542582 DOI: 10.1016/j.jsb.2013.03.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation