4IAE

Crystal structure of BAY 60-2770 bound to nostoc H-NOX domain

4IAE の概要

• エントリーDOI: 10.2210/pdb4iae/pdb
• 関連するPDBエントリー: 2O09 2O0C 2O0G 3L6J 4IAH 4IAM
• 分子名称: Alr2278 protein, 4-({(4-carboxybutyl)[2-(5-fluoro-2-{[4'-(trifluoromethyl)biphenyl-4-yl]methoxy}phenyl)ethyl]amino}methyl)benzoic acid, MALONATE ION, ... (4 entities in total)
• 機能のキーワード: activation, hnox domain, heme binding, no binding, lyase
• 由来する生物種: Nostoc sp.
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43916.56

構造登録者

Kumar, V.,van den Akker, F.,Martin, F. (登録日: 2012-12-06, 公開日: 2013-11-20, 最終更新日: 2023-09-20)

• 主引用文献: Kumar, V.,Martin, F.,Hahn, M.G.,Schaefer, M.,Stamler, J.S.,Stasch, J.P.,van den Akker, F.; Insights into BAY 60-2770 Activation and S-Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes.; Biochemistry, 52:3601-3608, 2013; PubMed: 23614626; DOI: 10.1021/bi301657w

実験手法

X-RAY DIFFRACTION (2.05 Å)