4I9Z
Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors
Summary for 4I9Z
Entry DOI | 10.2210/pdb4i9z/pdb |
Related | 4IA0 |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase, 5-bromo-2-{5-[(4-methylpiperazin-1-yl)acetyl]-2-propoxyphenyl}-6-(propan-2-yl)pyrimidin-4(3H)-one, ZINC ION, ... (6 entities in total) |
Functional Keywords | hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 40884.46 |
Authors | |
Primary citation | Gong, X.,Wang, G.,Ren, J.,Liu, Z.,Wang, Z.,Chen, T.,Yang, X.,Jiang, X.,Shen, J.,Jiang, H.,Aisa, H.A.,Xu, Y.,Li, J. Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5. Bioorg.Med.Chem.Lett., 23:4944-4947, 2013 Cited by PubMed: 23867165DOI: 10.1016/j.bmcl.2013.06.062 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.08 Å) |
Structure validation
Download full validation report