4I7F

HIV-1 Reverse Transcriptase in complex with a phosphonate analog of nevirapine

4I7F の概要

• エントリーDOI: 10.2210/pdb4i7f/pdb
• 分子名称: Reverse transcriptase, diethyl ({4-[2-(11-ethyl-5-methyl-6-oxo-6,11-dihydro-5H-dipyrido[3,2-b:2',3'-e][1,4]diazepin-8-yl)ethyl]phenoxy}methyl)phosphonate, SULFATE ION, ... (7 entities in total)
• 機能のキーワード: nnrti, hiv, reverse transcriptase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: HIV-1 M:B_HXB2R (HIV-1); 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 116966.01

構造登録者

Lansdon, E.B.,Parrish, J. (登録日: 2012-11-30, 公開日: 2013-02-20, 最終更新日: 2023-09-20)

• 主引用文献: Parrish, J.,Tong, L.,Wang, M.,Chen, X.,Lansdon, E.B.,Cannizzaro, C.,Zheng, X.,Desai, M.C.,Xu, L.; Synthesis and biological evaluation of phosphonate analogues of nevirapine.; Bioorg.Med.Chem.Lett., 23:1493-1497, 2013; PubMed: 23375792; DOI: 10.1016/j.bmcl.2012.12.049

実験手法

X-RAY DIFFRACTION (2.5 Å)