4I6Q

JAK3 kinase domain in complex with 2-Phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1-cyclopropyl-ethyl)-amide

4I6Q の概要

• エントリーDOI: 10.2210/pdb4i6q/pdb
• 分子名称: Tyrosine-protein kinase JAK3, 1-phenylurea, N-[(1S)-1-cyclopropylethyl]-2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, ... (4 entities in total)
• 機能のキーワード: kinase-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endomembrane system; Peripheral membrane protein (By similarity): P52333
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36072.11

構造登録者

Kuglstatter, A.,Shao, A. (登録日: 2012-11-30, 公開日: 2013-10-16, 最終更新日: 2023-09-20)

• 主引用文献: Jaime-Figueroa, S.,De Vicente, J.,Hermann, J.,Jahangir, A.,Jin, S.,Kuglstatter, A.,Lynch, S.M.,Menke, J.,Niu, L.,Patel, V.,Shao, A.,Soth, M.,Vu, M.D.,Yee, C.; Discovery of a series of novel 5H-pyrrolo[2,3-b]pyrazine-2-phenyl ethers, as potent JAK3 kinase inhibitors.; Bioorg.Med.Chem.Lett., 23:2522-2526, 2013; PubMed: 23541670; DOI: 10.1016/j.bmcl.2013.03.015

実験手法

X-RAY DIFFRACTION (1.85 Å)