4I5X
Crystal Structure Of AKR1B10 Complexed With NADP+ And Flufenamic acid
Summary for 4I5X
Entry DOI | 10.2210/pdb4i5x/pdb |
Related | 4GQ0 4GQG |
Descriptor | Aldo-keto reductase family 1 member B10, 2-[[3-(TRIFLUOROMETHYL)PHENYL]AMINO] BENZOIC ACID, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | tim barrel, aldo-keto reductase, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: O60218 |
Total number of polymer chains | 1 |
Total formula weight | 37306.39 |
Authors | |
Primary citation | Zhang, L.,Zhang, H.,Zhao, Y.,Li, Z.,Chen, S.,Zhai, J.,Chen, Y.,Xie, W.,Wang, Z.,Li, Q.,Zheng, X.,Hu, X. Inhibitor selectivity between aldo-keto reductase superfamily members AKR1B10 and AKR1B1: Role of Trp112 (Trp111) Febs Lett., 587:3681-3686, 2013 Cited by PubMed: 24100137DOI: 10.1016/j.febslet.2013.09.031 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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