4I4J

The structure of SgcE10, the ACP-polyene thioesterase involved in C-1027 biosynthesis

4I4J の概要

• エントリーDOI: 10.2210/pdb4i4j/pdb
• 分子名称: ACP-polyene thioesterase, D(-)-TARTARIC ACID, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: structural genomics, psi-biology, midwest center for structural genomics, mcsg, enzyme discovery for natural product biosynthesis, natpro, alpha-beta fold, hot-dog fold, esterase, hydrolase
• 由来する生物種: Streptomyces globisporus
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 145856.66

構造登録者

Kim, Y.,Bigelow, L.,Bearden, J.,Babnigg, J.,Bingman, C.A.,Yennamalli, R.,Lohman, J.,Ma, M.,Shen, B.,Phillips Jr., G.N.,Joachimiak, A.,Midwest Center for Structural Genomics (MCSG),Enzyme Discovery for Natural Product Biosynthesis (NatPro) (登録日: 2012-11-27, 公開日: 2012-12-12, 最終更新日: 2022-05-04)

• 主引用文献: Annaval, T.,Rudolf, J.D.,Chang, C.Y.,Lohman, J.R.,Kim, Y.,Bigelow, L.,Jedrzejczak, R.,Babnigg, G.,Joachimiak, A.,Phillips Jr., G.N.,Shen, B.; Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis.; Acs Omega, 2:5159-5169, 2017; PubMed: 28884166; DOI: 10.1021/acsomega.7b00933

実験手法

X-RAY DIFFRACTION (2.784 Å)