4I4E
Structure of Focal Adhesion Kinase catalytic domain in complex with hinge binding pyrazolobenzothiazine compound.
Summary for 4I4E
Entry DOI | 10.2210/pdb4i4e/pdb |
Related | 4EBV 4EBW 4I4F |
Descriptor | Focal adhesion kinase 1, [4-(2-hydroxyethyl)piperidin-1-yl][4-(5-methyl-4,4-dioxido-1,5-dihydropyrazolo[4,3-c][2,1]benzothiazin-8-yl)phenyl]methanone (3 entities in total) |
Functional Keywords | phosphorylated on tyrosines, transferase, cytoplasmic; localized to focal adhesions, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell junction, focal adhesion: Q05397 |
Total number of polymer chains | 1 |
Total formula weight | 32586.69 |
Authors | Skene, R.J.,Hosfield, D.J. (deposition date: 2012-11-27, release date: 2013-03-06, Last modification date: 2023-09-20) |
Primary citation | Tomita, N.,Hayashi, Y.,Suzuki, S.,Oomori, Y.,Aramaki, Y.,Matsushita, Y.,Iwatani, M.,Iwata, H.,Okabe, A.,Awazu, Y.,Isono, O.,Skene, R.J.,Hosfield, D.J.,Miki, H.,Kawamoto, T.,Hori, A.,Baba, A. Structure-based discovery of cellular-active allosteric inhibitors of FAK. Bioorg.Med.Chem.Lett., 23:1779-1785, 2013 Cited by PubMed: 23414845DOI: 10.1016/j.bmcl.2013.01.047 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.55 Å) |
Structure validation
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