4I3Z

Structure of pCDK2/CyclinA bound to ADP and 2 Magnesium ions

4I3Z の概要

• エントリーDOI: 10.2210/pdb4i3z/pdb
• 分子名称: Cyclin-dependent kinase 2, Cyclin-A2, ADENOSINE-5'-DIPHOSPHATE, ... (7 entities in total)
• 機能のキーワード: adp and magnesium binding, t160 phosphorylation, transferase-cell cycle complex, transferase/cell cycle
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome: P24941; Nucleus : P51943
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 128237.48

構造登録者

Jacobsen, D.M.,Bao, Z.-Q.,O'Brien, P.J.,Brooks, C.L.,Young, M.A. (登録日: 2012-11-27, 公開日: 2012-12-26, 最終更新日: 2017-11-15)

• 主引用文献: Jacobsen, D.M.,Bao, Z.-Q.,O'Brien, P.J.,Brooks, C.L.,Young, M.A.; Price To Be Paid for Two-Metal Catalysis: Magnesium Ions That Accelerate Chemistry Unavoidably Limit Product Release from a Protein Kinase; J.Am.Chem.Soc., 134:15357-15370, 2012; PubMed: 22891849

実験手法

X-RAY DIFFRACTION (2.05 Å)