4I3S

Crystal structure of the outer domain of HIV-1 gp120 in complex with VRC-PG04 space group P21

4I3S の概要

• エントリーDOI: 10.2210/pdb4i3s/pdb
• 関連するPDBエントリー: 3ngb 3se8 3se9 3tyg 4I3R
• 分子名称: Outer domain of HIV-1 gp120 (KER2018 OD4.2.2), Heavy chain of VRC-PG04 Fab, Light chain of VRC-PG04 Fab, ... (4 entities in total)
• 機能のキーワード: antibody affinity, antibody specificity, binding sites, hiv infections, antibodies, hiv envelope protein gp120, aids vaccines, amino acid sequence, antigens, epitopes, hiv antibodies, cd4, somatic mutation, sequence engineering, complementarity determining regions, immunoglobulin fab fragments, sera, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human Immunodeficiency Virus; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 68532.84

構造登録者

Joyce, M.G.,Biertumpfel, C.,Nabel, G.J.,Kwong, P.D. (登録日: 2012-11-26, 公開日: 2013-01-09, 最終更新日: 2023-12-27)

• 主引用文献: Joyce, M.G.,Kanekiyo, M.,Xu, L.,Biertumpfel, C.,Boyington, J.C.,Moquin, S.,Shi, W.,Wu, X.,Yang, Y.,Yang, Z.Y.,Zhang, B.,Zheng, A.,Zhou, T.,Zhu, J.,Mascola, J.R.,Kwong, P.D.,Nabel, G.J.; Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04.; J.Virol., 87:2294-2306, 2013; PubMed: 23236069; DOI: 10.1128/JVI.02717-12

実験手法

X-RAY DIFFRACTION (2.85 Å)