4I33

Crystal structure of HCV NS3/4A R155K protease complexed with compound 4

4I33 の概要

• エントリーDOI: 10.2210/pdb4i33/pdb
• 分子名称: Genome polyprotein, HCV non-structural protein 4A, SODIUM ION, ... (5 entities in total)
• 機能のキーワード: hepatitis c virus, ns3, ns4a, protein-inhibitor complex compound 4, serine protease, r155k, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Hepatitis C virus (HCV); 詳細
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein (By similarity). Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein. RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26662 P26662
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 44846.07

構造登録者

Lemke, C.T. (登録日: 2012-11-23, 公開日: 2013-01-02, 最終更新日: 2013-03-13)

• 主引用文献: O'Meara, J.A.,Lemke, C.T.,Godbout, C.,Kukolj, G.,Lagace, L.,Moreau, B.,Thibeault, D.,White, P.W.,Llinas-Brunet, M.; Molecular Mechanism by Which a Potent Hepatitis C Virus NS3-NS4A Protease Inhibitor Overcomes Emergence of Resistance.; J.Biol.Chem., 288:5673-5681, 2013; PubMed: 23271737; DOI: 10.1074/jbc.M112.439455

実験手法

X-RAY DIFFRACTION (1.9001 Å)