4I2Q
Crystal structure of K103N/Y181C mutant of HIV-1 reverse transcriptase in complex with rilpivirine (TMC278) analogue
4I2Q の概要
エントリーDOI | 10.2210/pdb4i2q/pdb |
分子名称 | Gag-Pol polyprotein, (2E)-3-(4-{[6-(1,3-benzothiazol-5-ylamino)-9H-purin-2-yl]amino}-3,5-dimethylphenyl)prop-2-enenitrile, 1,2-ETHANEDIOL, ... (5 entities in total) |
機能のキーワード | p51/p66, hetero dimer, nnrti, nonnucleoside inhibitor, aids, hiv, dna recombination, rna-directed dna polymerase, dna polymerase, endonuclease, hydrolase, multifunctional enzyme, transferase, transferase-inhibitor complex, transferase/inhibitor |
由来する生物種 | Human immunodeficiency virus type 1 BH10 (HIV-1) 詳細 |
細胞内の位置 | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 114454.19 |
構造登録者 | |
主引用文献 | Johnson, B.C.,Pauly, G.T.,Rai, G.,Patel, D.,Bauman, J.D.,Baker, H.L.,Das, K.,Schneider, J.P.,Maloney, D.J.,Arnold, E.,Thomas, C.J.,Hughes, S.H. A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants. Retrovirology, 9:99-99, 2012 Cited by PubMed: 23217210DOI: 10.1186/1742-4690-9-99 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.7004 Å) |
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