4I1R

Human MALT1 (caspase-IG3) in complex with thioridazine

Summary for 4I1R

Entry DOI	10.2210/pdb4i1r/pdb
Related	4I1P
Descriptor	Mucosa-associated lymphoid tissue lymphoma translocation protein 1, 10-{2-[(2S)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine (3 entities in total)
Functional Keywords	protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, perinuclear region: Q9UDY8
Total number of polymer chains	1
Total formula weight	44560.39
Authors	Schlauderer, F.,Lammens, K.,Hopfner, K.P. (deposition date: 2012-11-21, release date: 2013-08-28, Last modification date: 2024-02-28)
Primary citation	Schlauderer, F.,Lammens, K.,Nagel, D.,Vincendeau, M.,Eitelhuber, A.C.,Verhelst, S.H.,Kling, D.,Chrusciel, A.,Ruland, J.,Krappmann, D.,Hopfner, K.P. Structural Analysis of Phenothiazine Derivatives as Allosteric Inhibitors of the MALT1 Paracaspase. Angew.Chem.Int.Ed.Engl., 52:10384-10387, 2013 Cited by PubMed: 23946259 DOI: 10.1002/anie.201304290 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation