4I18

Crystal structure of human prolactin receptor complexed with Fab fragment

Summary for 4I18

Entry DOI	10.2210/pdb4i18/pdb
Descriptor	antibody light chain, antibody heavy chain, Prolactin receptor, ... (6 entities in total)
Functional Keywords	immunoglobulin fold, prolactin binding, receptor signaling, cytokine, signaling protein
Biological source	Mus musculus (mouse) More
Cellular location	Membrane ; Single-pass type I membrane protein . Isoform 7: Secreted: P16471
Total number of polymer chains	6
Total formula weight	147487.81
Authors	Duguid, E.M.,Mukherjee, S.,Kouadio, J.L. (deposition date: 2012-11-20, release date: 2013-11-20, Last modification date: 2024-10-16)
Primary citation	Rizk, S.S.,Kouadio, J.L.,Szymborska, A.,Duguid, E.M.,Mukherjee, S.,Zheng, J.,Clevenger, C.V.,Kossiakoff, A.A. Engineering synthetic antibody binders for allosteric inhibition of prolactin receptor signaling. Cell Commun Signal, 13:1-1, 2015 Cited by PubMed Abstract: Many receptors function by binding to multiple ligands, each eliciting a distinct biological output. The extracellular domain of the human prolactin receptor (hPRL-R) uses an identical epitope to bind to both prolactin (hPRL) and growth hormone (hGH), yet little is known about how each hormone binding event triggers the appropriate response. PubMed: 25589173 DOI: 10.1186/s12964-014-0080-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.238 Å)

Structure validation