4I0S

Crystal structure of spleen tyrosine kinase complexed with 2-(6-Chloro-1-methyl-1H-indazol-3-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid isopropylamide

Summary for 4I0S

• Entry DOI: 10.2210/pdb4i0s/pdb
• Related: 4I0R 4I0T
• Descriptor: Tyrosine-protein kinase SYK, 2-(6-chloro-1-methyl-1H-indazol-3-yl)-N-(propan-2-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide (3 entities in total)
• Functional Keywords: kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cell membrane : P43405
• Total number of polymer chains: 1
• Total formula weight: 34252.82

Authors

Kuglstatter, A.,Slade, M. (deposition date: 2012-11-19, release date: 2013-10-30, Last modification date: 2023-09-20)

• Primary citation: Padilla, F.,Bhagirath, N.,Chen, S.,Chiao, E.,Goldstein, D.M.,Hermann, J.C.,Hsu, J.,Kennedy-Smith, J.J.,Kuglstatter, A.,Liao, C.,Liu, W.,Lowrie, L.E.,Luk, K.C.,Lynch, S.M.,Menke, J.,Niu, L.,Owens, T.D.,O-Yang, C.,Railkar, A.,Schoenfeld, R.C.,Slade, M.,Steiner, S.,Tan, Y.C.,Villasenor, A.G.,Wang, C.,Wanner, J.,Xie, W.,Xu, D.,Zhang, X.,Zhou, M.,Lucas, M.C.; Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors.; J.Med.Chem., 56:1677-1692, 2013; PubMed: 23350847; DOI: 10.1021/jm301720p

Experimental method

X-RAY DIFFRACTION (1.98 Å)