Summary for 4I0P
| Entry DOI | 10.2210/pdb4i0p/pdb |
| Descriptor | HLA-DMA protein, HLA class II histocompatibility antigen, DM beta chain, HLA class II histocompatibility antigen, DO alpha chain, ... (9 entities in total) |
| Functional Keywords | hla-dm, hla-do, hla-dr, peptide loading, immune system, inhibitor, enzyme hla-dm |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 8 |
| Total formula weight | 172079.93 |
| Authors | Guce, A.I.,Mortimer, S.E.,Stern, L.J. (deposition date: 2012-11-18, release date: 2012-12-26, Last modification date: 2023-09-20) |
| Primary citation | Guce, A.I.,Mortimer, S.E.,Yoon, T.,Painter, C.A.,Jiang, W.,Mellins, E.D.,Stern, L.J. HLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanism. Nat.Struct.Mol.Biol., 20:90-98, 2013 Cited by PubMed: 23222639DOI: 10.1038/nsmb.2460 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.2 Å) |
Structure validation
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