4HZX

Crystal structure of influenza A neuraminidase N3 complexed with oseltamivir

Summary for 4HZX

• Entry DOI: 10.2210/pdb4hzx/pdb
• Related: 3TI6 4HZV 4HZW 4HZY 4HZZ 4I00
• Descriptor: Neuraminidase, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: neuraminidase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Influenza A virus
• Total number of polymer chains: 1
• Total formula weight: 44630.08

Authors

Li, Q.,Qi, J.,Vavricka, C.J.,Gao, G.F. (deposition date: 2012-11-15, release date: 2013-11-06, Last modification date: 2023-11-08)

• Primary citation: Li, Q.,Qi, J.,Wu, Y.,Kiyota, H.,Tanaka, K.,Suhara, Y.,Ohrui, H.,Suzuki, Y.,Vavricka, C.J.,Gao, G.F.; Functional and structural analysis of influenza virus neuraminidase N3 offers further insight into the mechanisms of oseltamivir resistance.; J.Virol., 87:10016-10024, 2013; PubMed: 23824808; DOI: 10.1128/JVI.01129-13

Experimental method

X-RAY DIFFRACTION (2.2 Å)