4HZT

Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates

4HZT の概要

• エントリーDOI: 10.2210/pdb4hzt/pdb
• 関連するPDBエントリー: 4I0Z 4I10 4I11
• 分子名称: Beta-secretase 1, ZINC ION, 3-{(1S)-1-[(6-chloro-3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)amino]-2-phenylethyl}-1,2,4-oxadiazol-5(2H)-one, ... (4 entities in total)
• 機能のキーワード: aspartic protease, hydrolysis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P56817
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 46038.22

構造登録者

Yao, N.,Brecht, E. (登録日: 2012-11-15, 公開日: 2013-03-06, 最終更新日: 2013-04-24)

• 主引用文献: Bowers, S.,Xu, Y.Z.,Yuan, S.,Probst, G.D.,Hom, R.K.,Chan, W.,Konradi, A.W.,Sham, H.L.,Zhu, Y.L.,Beroza, P.,Pan, H.,Brecht, E.,Yao, N.,Lougheed, J.,Tam, D.,Ren, Z.,Ruslim, L.,Bova, M.P.,Artis, D.R.; Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates.; Bioorg.Med.Chem.Lett., 23:2181-2186, 2013; PubMed: 23465612; DOI: 10.1016/j.bmcl.2013.01.103

実験手法

X-RAY DIFFRACTION (1.8 Å)