4HYS

Crystal structure of JNK1 in complex with JIP1 peptide and 4-(4-Indazol-1-yl-pyrimidin-2-ylamino)-cyclohexan

4HYS の概要

• エントリーDOI: 10.2210/pdb4hys/pdb
• 関連するPDBエントリー: 4HY4
• 分子名称: Mitogen-activated protein kinase 8, C-Jun-amino-terminal kinase-interacting protein 1, trans-4-{[4-(1H-indazol-1-yl)pyrimidin-2-yl]amino}cyclohexanol, ... (4 entities in total)
• 機能のキーワード: kinase inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cytoplasm (By similarity): Q9UQF2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 44243.17

構造登録者

Kuglstatter, A.,Janson, C. (登録日: 2012-11-14, 公開日: 2013-10-30, 最終更新日: 2023-09-20)

• 主引用文献: Palmer, W.S.,Alam, M.,Arzeno, H.B.,Chang, K.C.,Dunn, J.P.,Goldstein, D.M.,Gong, L.,Goyal, B.,Hermann, J.C.,Hogg, J.H.,Hsieh, G.,Jahangir, A.,Janson, C.,Jin, S.,Ursula Kammlott, R.,Kuglstatter, A.,Lukacs, C.,Michoud, C.,Niu, L.,Reuter, D.C.,Shao, A.,Silva, T.,Trejo-Martin, T.A.,Stein, K.,Tan, Y.C.,Tivitmahaisoon, P.,Tran, P.,Wagner, P.,Weller, P.,Wu, S.Y.; Development of amino-pyrimidine inhibitors of c-Jun N-terminal kinase (JNK): kinase profiling guided optimization of a 1,2,3-benzotriazole lead.; Bioorg.Med.Chem.Lett., 23:1486-1492, 2013; PubMed: 23352510; DOI: 10.1016/j.bmcl.2012.12.047

実験手法

X-RAY DIFFRACTION (2.415 Å)