4HY4

Crystal structure of cIAP1 BIR3 bound to T3170284

4HY4 の概要

• エントリーDOI: 10.2210/pdb4hy4/pdb
• 関連するBIRD辞書のPRD_ID: PRD_001139
• 分子名称: Baculoviral IAP repeat-containing protein 2, ZINC ION, (3S,8aR)-2-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-N-[(1R)-1,2,3,4-tetrahydronaphthalen-1-yl]octahydropyrrolo[1,2-a]pyrazine-3-carboxamide, ... (4 entities in total)
• 機能のキーワード: iap family, bir repeats, card domain, ring-type zinc finger, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: Q13490
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 27767.90

構造登録者

Dougan, D.R.,Mol, C.D.,Snell, G.P. (登録日: 2012-11-12, 公開日: 2013-01-30, 最終更新日: 2024-02-28)

• 主引用文献: Hashimoto, K.,Saito, B.,Miyamoto, N.,Oguro, Y.,Tomita, D.,Shiokawa, Z.,Asano, M.,Kakei, H.,Taya, N.,Kawasaki, M.,Sumi, H.,Yabuki, M.,Iwai, K.,Yoshida, S.,Yoshimatsu, M.,Aoyama, K.,Kosugi, Y.,Kojima, T.,Morishita, N.,Dougan, D.R.,Snell, G.P.,Imamura, S.,Ishikawa, T.; Design and Synthesis of Potent Inhibitor of Apoptosis (IAP) Proteins Antagonists Bearing an Octahydropyrrolo[1,2-a]pyrazine Scaffold as a Novel Proline Mimetic.; J.Med.Chem., 56:1228-1246, 2013; PubMed: 23298277; DOI: 10.1021/jm301674z

実験手法

X-RAY DIFFRACTION (1.249 Å)