4HXX

Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1

Summary for 4HXX

Entry DOI	10.2210/pdb4hxx/pdb
Descriptor	Methionine aminopeptidase 1, COBALT (II) ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywords	aminopeptidases, pyrimidines, pyrimidyl group, pyridinylpyrimidine, cell cycle, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35093.40
Authors	Gabelli, S.B.,Zhang, F.,Liu, J.,Amzel, L.M. (deposition date: 2012-11-12, release date: 2013-04-03, Last modification date: 2024-02-28)
Primary citation	Zhang, P.,Yang, X.,Zhang, F.,Gabelli, S.B.,Wang, R.,Zhang, Y.,Bhat, S.,Chen, X.,Furlani, M.,Amzel, L.M.,Liu, J.O.,Ma, D. Pyridinylpyrimidines selectively inhibit human methionine aminopeptidase-1. Bioorg.Med.Chem., 21:2600-2617, 2013 Cited by PubMed: 23507151 DOI: 10.1016/j.bmc.2013.02.023 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.09 Å)

Structure validation