4HX5
Crystal structure of 11 beta-HSD1 in complex with SAR184841
4HX5 の概要
エントリーDOI | 10.2210/pdb4hx5/pdb |
分子名称 | Corticosteroid 11-beta-dehydrogenase isozyme 1, 4-[5-(4-tert-butylpiperazin-1-yl)pyridin-2-yl]-N-[(1R,2S,3S,5S,7s)-5-carbamoyltricyclo[3.3.1.1~3,7~]dec-2-yl]-3,4-dihydroquinoxaline-1(2H)-carboxamide, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
機能のキーワード | 11beta, hydroxysteroid, dehydrogenase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
由来する生物種 | Homo sapiens (human) |
細胞内の位置 | Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 132616.21 |
構造登録者 | |
主引用文献 | Venier, O.,Pascal, C.,Braun, A.,Namane, C.,Mougenot, P.,Crespin, O.,Pacquet, F.,Mougenot, C.,Monseau, C.,Onofri, B.,Dadji-Faihun, R.,Leger, C.,Ben-Hassine, M.,Van-Pham, T.,Ragot, J.L.,Philippo, C.,Farjot, G.,Noah, L.,Maniani, K.,Boutarfa, A.,Nicolai, E.,Guillot, E.,Pruniaux, M.P.,Gussregen, S.,Engel, C.,Coutant, A.L.,de Miguel, B.,Castro, A. Discovery of SAR184841, a potent and long-lasting inhibitor of 11beta-hydroxysteroid dehydrogenase type 1, active in a physiopathological animal model of T2D Bioorg.Med.Chem.Lett., 23:2414-2421, 2013 Cited by PubMed: 23478147DOI: 10.1016/j.bmcl.2013.02.018 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.19 Å) |
構造検証レポート
検証レポート(詳細版)
をダウンロード
![ダウンロード](/newweb/media/icons/dl.png)