4HWT

Crystal structure of human Threonyl-tRNA synthetase bound to a novel inhibitor

4HWT の概要

• エントリーDOI: 10.2210/pdb4hwt/pdb
• 関連するPDBエントリー: 4HWO 4HWP 4HWR 4HWS
• 分子名称: Threonine--tRNA ligase, cytoplasmic, ZINC ION, N-{[3-(2H-indazol-5-yl)phenyl]sulfonyl}-L-threoninamide, ... (4 entities in total)
• 機能のキーワード: aminoacyl-trna synthetase, protein-inhibitor complex, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P26639
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97831.84

構造登録者

Hilgers, M.T. (登録日: 2012-11-08, 公開日: 2013-09-18)

• 主引用文献: Teng, M.,Hilgers, M.T.,Cunningham, M.L.,Borchardt, A.,Locke, J.B.,Abraham, S.,Haley, G.,Kwan, B.P.,Hall, C.,Hough, G.W.,Shaw, K.J.,Finn, J.; Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.; J.Med.Chem., 56:1748-1760, 2013; PubMed: 23362938; DOI: 10.1021/jm301756m

実験手法

X-RAY DIFFRACTION (2.3 Å)