4HWR
Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor
Summary for 4HWR
Entry DOI | 10.2210/pdb4hwr/pdb |
Related | 4HWO 4HWP 4HWS 4HWT |
Descriptor | Threonine--tRNA ligase, ZINC ION, N-{[3-(2H-indazol-5-yl)phenyl]sulfonyl}-L-threoninamide, ... (4 entities in total) |
Functional Keywords | aminoacyl-trna synthetase, protein-inhibitor complex, antibacterial, ligase-ligase inhibitor complex, ligase/ligase inhibitor |
Biological source | Escherichia coli |
Cellular location | Cytoplasm: P0A8M3 |
Total number of polymer chains | 2 |
Total formula weight | 96876.83 |
Authors | Hilgers, M.T. (deposition date: 2012-11-08, release date: 2013-09-18, Last modification date: 2024-02-28) |
Primary citation | Teng, M.,Hilgers, M.T.,Cunningham, M.L.,Borchardt, A.,Locke, J.B.,Abraham, S.,Haley, G.,Kwan, B.P.,Hall, C.,Hough, G.W.,Shaw, K.J.,Finn, J. Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design. J.Med.Chem., 56:1748-1760, 2013 Cited by PubMed: 23362938DOI: 10.1021/jm301756m PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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