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4HWO

Crystal structure of E. coli Threonyl-tRNA synthetase bound to a novel inhibitor

Summary for 4HWO
Entry DOI10.2210/pdb4hwo/pdb
Related4HWP 4HWR 4HWS 4HWT
DescriptorThreonine--tRNA ligase, ZINC ION, N-{[3-(4-aminoquinazolin-7-yl)phenyl]sulfonyl}-L-threoninamide, ... (4 entities in total)
Functional Keywordsaminoacyl-trna synthetase, protein-inhibitor complex, antibacterial, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological sourceEscherichia coli
Cellular locationCytoplasm: P0A8M3
Total number of polymer chains2
Total formula weight96930.89
Authors
Hilgers, M.T. (deposition date: 2012-11-08, release date: 2013-09-18, Last modification date: 2024-02-28)
Primary citationTeng, M.,Hilgers, M.T.,Cunningham, M.L.,Borchardt, A.,Locke, J.B.,Abraham, S.,Haley, G.,Kwan, B.P.,Hall, C.,Hough, G.W.,Shaw, K.J.,Finn, J.
Identification of bacteria-selective threonyl-tRNA synthetase substrate inhibitors by structure-based design.
J.Med.Chem., 56:1748-1760, 2013
Cited by
PubMed: 23362938
DOI: 10.1021/jm301756m
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.907 Å)
Structure validation

217705

건을2024-03-27부터공개중

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