4HVS
Crystal structure of KIT kinase domain with a small molecule inhibitor, PLX647
Summary for 4HVS
Entry DOI | 10.2210/pdb4hvs/pdb |
Descriptor | Mast/stem cell growth factor receptor Kit, 5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[4-(trifluoromethyl)benzyl]pyridin-2-amine (3 entities in total) |
Functional Keywords | transferase, tyrosine-protein kinase, atp-binding, kinase-kinase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Cell membrane; Single-pass type I membrane protein. Isoform 3: Cytoplasm: P10721 |
Total number of polymer chains | 1 |
Total formula weight | 38424.48 |
Authors | |
Primary citation | Zhang, C.,Ibrahim, P.N.,Zhang, J.,Burton, E.A.,Habets, G.,Zhang, Y.,Powell, B.,West, B.L.,Matusow, B.,Tsang, G.,Shellooe, R.,Carias, H.,Nguyen, H.,Marimuthu, A.,Zhang, K.Y.,Oh, A.,Bremer, R.,Hurt, C.R.,Artis, D.R.,Wu, G.,Nespi, M.,Spevak, W.,Lin, P.,Nolop, K.,Hirth, P.,Tesch, G.H.,Bollag, G. Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc.Natl.Acad.Sci.USA, 110:5689-5694, 2013 Cited by PubMed: 23493555DOI: 10.1073/pnas.1219457110 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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