4HVD

JAK3 kinase domain in complex with 2-Cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((S)-1,2,2-trimethyl-propyl)-amide

4HVD の概要

• エントリーDOI: 10.2210/pdb4hvd/pdb
• 関連するPDBエントリー: 4HVG 4HVH 4HVI
• 分子名称: Tyrosine-protein kinase JAK3, 1-phenylurea, 2-cyclopropyl-N-[(2S)-3,3-dimethylbutan-2-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide, ... (4 entities in total)
• 機能のキーワード: kinase-inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endomembrane system; Peripheral membrane protein (By similarity): P52333
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 36036.12

構造登録者

Kuglstatter, A.,Shao, A. (登録日: 2012-11-06, 公開日: 2013-01-16, 最終更新日: 2023-09-20)

• 主引用文献: Soth, M.,Hermann, J.C.,Yee, C.,Alam, M.,Barnett, J.W.,Berry, P.,Browner, M.F.,Frank, K.,Frauchiger, S.,Harris, S.,He, Y.,Hekmat-Nejad, M.,Hendricks, T.,Henningsen, R.,Hilgenkamp, R.,Ho, H.,Hoffman, A.,Hsu, P.Y.,Hu, D.Q.,Itano, A.,Jaime-Figueroa, S.,Jahangir, A.,Jin, S.,Kuglstatter, A.,Kutach, A.K.,Liao, C.,Lynch, S.,Menke, J.,Niu, L.,Patel, V.,Railkar, A.,Roy, D.,Shao, A.,Shaw, D.,Steiner, S.,Sun, Y.,Tan, S.L.,Wang, S.,Vu, M.D.; 3-Amido Pyrrolopyrazine JAK Kinase Inhibitors: Development of a JAK3 vs JAK1 Selective Inhibitor and Evaluation in Cellular and in Vivo Models.; J.Med.Chem., 56:345-356, 2013; PubMed: 23214979; DOI: 10.1021/jm301646k

実験手法

X-RAY DIFFRACTION (1.85 Å)