4HTZ

Crystal structure of PDE2 catalytic domain in space group P1

Summary for 4HTZ

Entry DOI	10.2210/pdb4htz/pdb
Related	4HTX
Descriptor	cGMP-dependent 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (4 entities in total)
Functional Keywords	hydrolase
Biological source	Homo sapiens (human)
Cellular location	Isoform PDE2A3: Cell membrane ; Lipid-anchor . Isoform PDE2A2: Mitochondrion matrix . Isoform PDE2A1: Cytoplasm . Isoform 5: Mitochondrion : O00408
Total number of polymer chains	4
Total formula weight	160221.96
Authors	Zhu, J.,Huang, Q. (deposition date: 2012-11-02, release date: 2013-08-28, Last modification date: 2024-02-28)
Primary citation	Zhu, J.,Yang, Q.,Dai, D.,Huang, Q. X-ray Crystal Structure of Phosphodiesterase 2 in Complex with a Highly Selective, Nanomolar Inhibitor Reveals a Binding-Induced Pocket Important for Selectivity. J.Am.Chem.Soc., 135:11708-11711, 2013 Cited by PubMed: 23899287 DOI: 10.1021/ja404449g PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation